An explosion near a mosque in a Shia area of the Pakistani city of Karachi has killed at least 45 people and injured dozens more, police say.

An MP is calling on police to boost its probe into child sex grooming allegations in Greater Manchester.

Delegates from 178 countries will review the convention on international trade in endangered species (CITES) amidst an unprecedented extinction crisis.

Syrian President Bashar al-Assad accuses the UK government of bullying and naivety over the conflict in his country, in a rare British newspaper interview.

Rescue teams in Florida call off efforts to recover the body of a man swallowed by a sinkhole under his home, and say the house will be destroyed.

Many nurses believe the NHS has a culture that discourages staff from raising concerns about patient care, a survey suggests.

A charity warns that plans to increase the number of children per nursery worker could lead to a two-tier system, with a drop in quality in poor areas.

Medical reports could determine whether the Qatar World Cup in 2022 is moved to winter, a Fifa official admits.